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How much CBD is right for me?

Determining a standard dose for CBD is a moving target, at best. Until the US medicinal cannabis industry develops a central authority and publishes valid research, we will have to rely on credible studies from overseas, the experiences of seasoned users, and our own diligence and discretion. The good news is that because CBD is not toxic, it’s difficult to make a mistake when trying to establish how much is right for you. Our personal experience shows that for most everyone, pets included, it’s a good idea to “start small and work your way up,” when it comes to adding CBD to your health supplement regimen. People who have more experience with CBD may be able to start at higher doses, as can people who are under the care of a cannabis-informed health care provider. Our Endocannabinoid Systems build up a “cumulative effect,” meaning the receptor sites fill up over time to a point of saturation, so taking ever-increasing doses of CBD does not necessarily increase the effect of CBD in the body. Micro-dosing is currently being studied, and many people report good to excellent results from adhering to that adage, “Less is more.” Here are some guidelines to help you decide what’s right for you.

To start:

For generally healthy people who are interested in CBD’s role in disease prevention, slowing the aging process, and protecting the brain and heart, and for those who are new to CBD, we recommend starting at a low amount, such as 10-25mg per day, divided into two doses, morning and night. Taking it on an empty stomach increases the speed at which the CBD is delivered into your system, but taking it with food, especially foods with fats in them, increases the potency. That’s because CBD is lipophilic, meaning it has an affinity for fat, which helps it penetrate body tissues and protects some of the ingested CBD from being neutralized by the liver. MediPrana CBD Oil tinctures and sprays are suspended in a carrier oil (base) that includes fractionated coconut oil, as coconut oil fats help the product absorb better.

  • 5-25mg per day, preferably divided into 2-4 doses.
  • After a few days, increase by a few milligrams per day and maintain that dosage for a few more days. The idea is to go slowly and work your way up as your body adjusts.
  • Continue to increase in small increments until you feel like you are getting the correct amount for you. Most people report that they feel comfortable with daily dosing in the range of 10-70mg per day.

For people dealing with a serious illness or multiple health issues, or who are using strong pain medication, they may elect to start at a higher dose. We always recommend that you consult with a knowledgeable health care provider who is familiar with your health concerns to collaborate with you on your care plan, especially if you are taking medications.

  • CBD is not a drug. Many new users feel anxious if they do not receive exact dosing instructions because they are accustomed to the “drug model” of prescribing a specific dosage that fits most, even though medications are definitely not “one size fits all.” Medications are prescribed this way because A) they can be toxic if taken in large doses and B) standardized (low) dosing provides a modicum of protection from liability.
  • CBD is non-toxic. There have been no reported drug-related injuries or deaths from application, ingestion, or inhalation of CBD.  Furthermore, there are no established dosage thresholds that have been observed to lead to toxicity and related side effects in humans.  However, we still recommend that any hemp or cannabis derivative be avoided by women who are pregnant or lactating as we simply do not have enough evidence to establish clear margins of safety.
  • Everyone’s metabolisms are unique and determines the pathways and speeds at which they metabolize various substances, including plant compounds. Factors that affect rates of metabolism include: health, hydration, genetic factors, smoking, the environment, activity levels, stress, body composition, and weight.
  • The method of delivery also affects how much CBD will be absorbed. Generally, inhalation will deliver the highest (and fastest) amounts of active ingredient, then sublingual (under the tongue) absorption, then suppositories, then topical (on the skin application), and finally, ingestion.  The reason rates of absorption for ingestion are lower is because part of the active ingredient makes its way into the bloodstream quickly and part makes its way to the liver where, depending on one’s genetic make-up, it is quickly de-activated and eliminated from the body (See CP450 page for more information). The pH in the gut also fluctuates and that can alter the bioavailability of CBD as well.
  • The quality of the product, how it’s been manufactured, and how the CBD oil has been handled can also change how much CBD is needed to create the desired effect. For instance, MediPrana’s Nano-enhancement process increases the bioavailability of the CBD up to ten times over similar product that has been prepared without nanotechnology
  • The ideal dose of CBD oil will also depend on whether the product is produced from CBD isolate or if it’s full spectrum, meaning other plant compounds have not been removed. Numerous credible studies have shown that the compounds in the cannabis plant activate different receptor sites, working together to multiply the positive effect on the body. For many conditions, a ratio of CBD to TCH anywhere from 20:1 to 1:1 has been reported to better ameliorate symptoms. This is called “The Entourage Effect.” While you can still benefit from CBD isolate products, full-spectrum may have a slight advantage; however, CBD isolate still provides powerful anti-inflammatory effect without the worry of testing positive for TCH. It is important to know whether the CBD product you are purchasing is “full-spectrum” or “isolate,” depending on your needs.
  • CBD is bi-phasic, meaning CBD’s effects vary depending on the concentration (amount) in the body. For instance, CBD at low to medium concentrations generally causes a state of “relaxed alertness,” while higher concentrations can lead to “calm sedation.” Both effects can be beneficial, but you may not want to be “calm and sedate” on your way to a sporting event with friends just as bedtime may not be the ideal time to experience the brain-stimulating effects that lower-dose CBD can facilitate as well.
  • MediPrana’s CBD tinctures, sprays, and lotions are also nano-enhanced, which increases the percentage of CBD that is absorbed and actively used by the body, so you will have greater effect than from a non-nano product. If you still have questions regarding the right dose for you, please call us at (866) 420-3571 and ask to speak with a knowledgeable customer care specialist, so we can steer you in the right direction. Again, please keep in mind that CBD is a natural, non-toxic plant compound with a low probability of causing any undesirable effects. No studies have ever established that there is a lethal dose of CBD in humans.

Please keep in mind:

There is no such thing as a “cure-all,” and while CBD seems temptingly close to that possibility, remember that CBD supplies the body with missing elements that it needs for maintaining homeostasis, or the ability to repair its own cells and tissues. While the CBD can be instrumental in helping the body repair and maintain itself, the real work is done by our bodies. It’s important to regularly engage in health-promoting behaviors—eating well, exercising, getting enough sleep—to provide the body with other crucial compounds and building blocks that it needs to keep us well. Imagine having a toolbox with only a hammer inside. That comes in handy when a picture needs to be hung but not so useful for mending a teacup handle. The more tools you have at your disposal, CBD included, the easier it is to maintain a healthy body and mind. Everyone’s response to their environment, foods, supplements, and a host of other factors can affect their ideal dosage. And these factors can change over time, so what works for you today may not meet your needs in the future. Please be observant of your body’s individual responses and check in regularly with a trusted health advisor to ensure you get the best result.

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